Mise au point de nouvelles réactions et l'application de celles-ci à la synthèse de produits naturels biologiquement actifs. L'utilisation de peroxydes comme intermédiaires en chimie organique. Conception et développement de nouveaux composés antipaludiques et antiviraux.
Publications récentes
- «Direct Observation of Molecular Preorganization for Chirality Transfer on a Catalyst Surface», V. Demers-Carpentier, G. Goubert, F. Masini, R. Lafleur-Lambert, Y. Dong, S. Lavoie, G. Mahieu, J. Boukouvalas, H. Gao, A. M. H. Rasmussen, L. Ferrighi, Y. Pan, B. Hammer and P. H. McBreen, Science 2011, 334, 776-780.
- «Synthesis of the Hypoxic Signaling Inhibitor Furospongolide», J. Boukouvalas and V. Albert, Synlett 2011, 2541-2544.
- «Oxidative Rearrangement of 2-Furylcarbamates with Dimethyldioxirane: a High-yielding Preparation of 5-Hydroxypyrrol-2(5H)-ones», J. Boukouvalas, R. P. Loach and E. Ouellet, Tetrahedron Lett. 2011, 52, 4636-4639.
- «Concise, Regiocontrolled Synthesis of Yangjinhualine A», J. Boukouvalas and L. C. McCann, Tetrahedron Lett. 2011, 52, 1202-1204.
- «Synthesis of the Human Aldose Reductase Inhibitor Rubrolide L», J. Boukouvalas and L. C. McCann, Tetrahedron Lett. 2010, 51, 4636-4639.
- «General, Regiodefined Access to a-Substituted Butenolides through Metal-Halogen Exchange of 3-Bromo-2-silyloxyfurans. Efficient Synthesis of an Anti-inflammatory Gorgonian Lipid», J. Boukouvalas and R.P. Loach, J. Org. Chem. 2008, 73, 8109-8112.
- «Structure Revision and Synthesis of a Novel Labdane Diterpenoid from Zingiber ottensii», J. Boukouvalas and J.-X. Wang, Org. Lett. 2008, 10, 3397-3399.
- «Dimethyldioxirane Oxidation of 2-Silyloxypyrroles: An Efficient Regiocontrolled Synthesis of 5-Hydroxy-3-pyrrolin-2-ones», J. Boukouvalas, Y. Xiao, Y.-X. Cheng and R. P. Loach, Synlett 2007, 3198-3200.
- «Expedient Synthesis of Villosin and its Isomer (E)-Labda-8(17),12,14-trien-15(16)-olide», J. Boukouvalas, J.-X. Wang and O. Marion, Tetrahedron Lett. 2007, 48, 7747-7750.
- «A Concise Asymmetric Synthesis of (+)-Muscarine from (S)-g-Hydroxymethyl-g-butyrolactone», J. Boukouvalas and I.-I. Radu, Tetrahedron Lett. 2007, 48, 2971-2973.
- «A New, Highly Stereoselective Synthesis of b-Unsubstituted (Z)-g-Alkylidenebutenolides Using Bromine as a Removable Stereocontrol Element», J. Boukouvalas, P. P. Beltrán, N. Lachance, S. Côté, F. Maltais, M. Pouliot, Synlett. 2007, 219-222.
- «Facile Access to 4-(1-Alkynyl)-2(5H)-furanones by Sonogashira Coupling of Terminal Acetylenes with b-Tetronic Acid Bromide: Efficient Synthesis of Cleviolide», J. Boukouvalas, S. Côté and B. Ndzi, Tetrahedron Lett. 2007, 48, 105-107.
- «Asymmetric Total Synthesis of (-)-Panacene and Correction of Its Relative Configuration» J. Boukouvalas, M. Pouliot, J. Robichaud, S. MacNeil and V. Snieckus, Org. Lett. 2006, 8, 3597-3599.
- «Synthesis and Stereochemistry of the Antitumor Diterpenoid Zerumin B», J. Boukouvalas, J.-X. Wang, O. Marion and B. Ndzi, J. Org. Chem. 2006, 71, 6670-6673.
- «A Unified Strategy for the Regiospecific Assembly of Homoallyl-subsituted Butenolides and g-Hydroxybutenolides: First Synthesis of Luffariellolide», J. Boukouvalas, J. Robichaud and F. Maltais, Synlett 2006, 2480-2482.
- «Efficient Synthesis of (E)-3-Alkylidene-2(3H)-furanones from 3-(1-Hydroxyalkyl)-2-silyloxyfurans», J. Boukouvalas and O. Marion, Synlett 2006, 1511-1514.
- «Short and Efficient Synthesis of Cadiolide B», J. Boukouvalas and M. Pouliot, Synlett 2005, 343-345.
- «Steady-state Kinetics and Inhibition of Anaerobically Purified Human Homogentisate 1,2-Dioxygenase», E. J. A. Veldhuizen, F. H. Vaillancourt, C. J. Whiting, M. M.-Y. Hsiao, G. Gingras, Y. Xiao, R. M. Tanguay, J. Boukouvalas and L. D. Eltis, Biochem. J. 2005, 386, 305-314.
|
|
 |
